A Novel Enzymatic Approach to the Synthesis of Chiral Sulfoxides: Enzymatic Hydrolysis of Prochiral Sulfinyldicarboxylates
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (02) , 127-129
- https://doi.org/10.1055/s-1994-22765
Abstract
Methoxycarbonylmethyl carboxymethyl sulfoxide 3 and 2-acetoxyethyl 2-hydroxyethyl sulfoxide 4 have been obtained in high enantiomeric purity by the enzyme-mediated hydrolysis of the corresponding prochiral sulfinyldicarboxylates 1 and 2. The R configuration has been assigned to the enantiomerically pure (-)-3, [α]D 20 -20, by X-ray analysis.Keywords
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