Human biological relevance and the use of threshold-arguments in regulatory genotoxicity assessment: experience with pharmaceuticals

This publication has 27 references indexed in Scilit:

• Interpretation of the biological relevance of genotoxicity test results: the importance of thresholds
  Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2000
• ICH-Harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact
  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999
• Genotoxicity testing of biotechnology-derived products
  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1999
• Fluoroquinolone antibacterials enhance UVA-induced skin tumors
  Journal of Photochemistry and Photobiology B: Biology, 1997
• The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conversion and DNA breakage (Comet assay)
  Mutagenesis, 1996
• Anticancer drugs: an underestimated risk or an underutilised resource in mutagenesis?
  Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1995
• Genotoxicity of 17 gyrase- and four mammalian topoisomerase II-poisons in prokaryotic and eukaryotic test systems
  Mutagenesis, 1995
• An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro: Studies with human and rat liver microsomes
  Biochemical Pharmacology, 1993
• The quality of genotoxicity testing of drugs. Experiences of a regulatory agency with new and old compounds
  Mutagenesis, 1991
• Cytogenetic assay of potential mutagenicity in vivo of two narcotic analgesics
  Mutation Research/Genetic Toxicology, 1980