Catechol Estrogen Formation in the Central Nervous System of the Rat
- 1 April 1975
- journal article
- Published by The Endocrine Society in Endocrinology
- Vol. 96 (4) , 1054-1059
- https://doi.org/10.1210/endo-96-4-1054
Abstract
Conversion of estradiol and estrone to catechol estrogens by rat hypothalamic tissue but not by the cerebral cortex was demonstrated from the incubation of these tissues with estradiol-2-3H and estrone-2-3H and monitoring the incorporation of tritium into water. Direct evidence for this transformation was obtained by isolating the labelled phenazine derivative of 2-hydroxyestrone after hypothalamic incubation with estrone-4-14C.Keywords
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