Postinfectional inhibitors from plants. XXIII. Sesquiterpenoid phytoalexins from fruit capsules of Datura stramonium

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Abstract
D. stramonium fruit capsules inoculated with Monilinia fructicola or several other nonpathogenic fungi produced diffusates inhibitory to M. fructicola in spore germination assays. Detailed analysis of diffusates that were induced by M. fructicola indicated that they were complex and that antifungal activity was widely distributed through a number of column chromatographic fractions. Four compounds were isolated. These were sesquiterpenes, 3 of which, lubimin, hydroxylubimin and capsidiol, are described from other Solanaceae. The 4th, 2,3-dihydroxygermacrene, is a new compound with moderate antifungal activity but which is of special interest as a possible precursor of several phytoalexins in the Solanaceae.