Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
- 1 August 1983
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 304 (5926) , 507-513
- https://doi.org/10.1038/304507a0
Abstract
Kirsten (Ki)-ras cDNA clones were prepared from human lung and colon carcinoma cell lines expressing an activated c-Ki-ras2 gene. DNA sequence analysis and transfection studies indicate that different point mutations at the same codon can activate the gene; that most human c-Ki-ras2 mRNA uses sequences from a fourth coding exon distinct from that of its viral counterpart; and that at least one cell line is functionally homozygous for the activated gene.This publication has 49 references indexed in Scilit:
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