Modulator binding protein antagonizes activation of (Ca2+ + Mg2+)‐ATPase and Ca2+ transport of red blood cell membranes
- 1 January 1978
- journal article
- research article
- Published by Wiley in Journal of Supramolecular Structure
- Vol. 9 (2) , 269-274
- https://doi.org/10.1002/jss.400090211
Abstract
Red blood cells contain a protein that activates membrane-bound (Ca2+ + Mg2+)-ATPase and Ca2+ transport. The red blood cell activator protein is similar to a modulator protein that stimulates cyclic AMP phosphodiesterase. Wang and Desai [Journal of Biological Chemistry 252:4175–4184, 1977] described a modulator-binding protein that antagonizes the activation of cyclic AMP phosphodiesterase by modulator protein. In the present work, modulator-binding protein was shown to antagonize the activation of (Ca2+ + Mg2+)-ATPase and Ca2+ transport by red blood cell activator protein. The results further demonstrate the similarity between the activator protein from human red blood cells and the modulator protein from bovine brain.Keywords
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