Structure and function of AMPA receptors
- 12 January 2004
- journal article
- review article
- Published by Wiley in The Journal of Physiology
- Vol. 554 (2) , 249-253
- https://doi.org/10.1113/jphysiol.2003.054320
Abstract
The application of X‐ray diffraction has allowed the structure of the ligand‐binding core of AMPA receptors to be determined. Here I review the insights that this has given into the molecular mechanisms of activation and desensitization of these receptors.Keywords
This publication has 14 references indexed in Scilit:
- Mechanism of glutamate receptor desensitizationNature, 2002
- The structure and function of glutamate receptor ion channelsNature Reviews Neuroscience, 2002
- Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate ReceptorNeuron, 2000
- Pharmacology of AMPA/Kainate Receptor Ligands and Their Therapeutic Potential in Neurological and Psychiatric DisordersDrugs, 2000
- The Glutamate Receptor Ion ChannelsPharmacological Reviews, 1999
- Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable constructProtein Science, 1998
- Structure of a glutamate-receptor ligand-binding core in complex with kainateNature, 1998
- A Point Mutation in the Glutamate Binding Site Blocks Desensitization of AMPA ReceptorsNeuron, 1998
- The macro- and microarchitectures of the ligand-binding domain of glutamate receptorsTrends in Neurosciences, 1998
- Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteinsNeuron, 1994