Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barre syndrome.
- 1 June 1997
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 62 (6) , 641-643
- https://doi.org/10.1136/jnnp.62.6.641
Abstract
To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barré syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barré syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barré syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guillain-Barré syndrome associated with CMV.Keywords
This publication has 13 references indexed in Scilit:
- Association of anti-GM2 antibodies in Guillain-Barré syndrome with acute cytomegalovirus infectionJournal of Neuroimmunology, 1996
- Campylobacter jejuni infections and anti‐GM1 antibodies in guillain‐barré syndromeAnnals of Neurology, 1996
- Anti‐ganglioside GM1 antibodies in guillain‐barré syndrome and their relationship to Campylobacter jejuni infectionAnnals of Neurology, 1995
- Guillain-Barr syndrome and chronic inflammatory demyelinating polyneuropathy: Immune mechanisms and update on current therapiesAnnals of Neurology, 1995
- Anti‐gal‐C antibody in autoimmune neuropathies subsequent to mycoplasma infectionMuscle & Nerve, 1995
- A bacterium lipopolysaccharide that elicits Guillain-Barré syndrome has a GM1 ganglioside-like structure.The Journal of Experimental Medicine, 1993
- Sural nerve biopsies in Guillain‐Barre syndrome: Axonal degeneration and macrophage‐associated demyelination and absence of cytomegalovirus genomeMuscle & Nerve, 1992
- Anti-GM1 IgA antibodies in Guillain-Barré syndromeJournal of Neuroimmunology, 1992
- Antibody detection in Guillain-Brr syndromeAnnals of Neurology, 1990
- A prospective study of acute idiopathic neuropathy. II. Antecedent events.Journal of Neurology, Neurosurgery & Psychiatry, 1988