Resveratrol Inhibits Cyclooxygenase‐2 Transcription in Human Mammary Epithelial Cells

Publisher Website
Google Scholar
Abstract
A large body of evidence suggests that inhibiting cyclooxygenase‐2 (COX‐2), the inducible form of COX, will be an important strategy for preventing cancer. In this study, we investigated whether resveratrol, a chemopreventive agent found in grapes, could suppress phorbol ester (PMA)‐mediated induction of COX‐2 in human mammary and oral epithelial cells. Treatment of cells with PMA induced COX‐2 mRNA, COX‐2 protein, and prostaglandin synthesis. These effects were inhibited by resveratrol. Nuclear runoffs revealed increased rates of COX‐2 transcription after treatment with PMA, an effect that was inhibited by resveratrol. Resveratrol inhibited PMA‐mediated activation of protein kinase C and the induction of COX‐2 promoter activity by c‐Jun. Phorbol ester‐mediated induction of AP‐1 activity was blocked by resveratrol. These data are likely to be important for understanding the anticancer and anti‐inflammatory properties of resveratrol.

This publication has 23 references indexed in Scilit: