Increased Urea Solubility of the Blood Clot in Chronic Granulocytic Leukemia and its Relation to the Abnormal Thrombelastogram

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Abstract
The whole blood clots of patients with chronic granulocytic leukemia are more soluble in 5 M urea than are normal blood clots. This finding correlates with the abnormal thrombelastogram (step-phenomenon) which is seen in this disorder. Like the step-phenomenon, the abnormal urea solubility requires the presence of white cells or platelets or both. The abnormal TEG, but not the increased urea solubility, can be corrected by reduced glutathione, 0.01 M. The increased urea solubility is probably due to a potentiation of protelysis rather than an inhibition of fibrin stabilizing factor.

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