Reduced extinction of hippocampal-dependent memories in CPEB knockout mice
- 1 January 2006
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 13 (1) , 4-7
- https://doi.org/10.1101/lm.73706
Abstract
CPEB is a sequence-specific RNA binding protein that regulates translation at synapses. In neurons of CPEB knockout mice, synaptic efficacy is reduced. Here, we have performed a battery of behavioral tests and find that relative to wild-type animals, CPEB knockout mice, although similar on many baseline behaviors, have reduced extinction of memories on two hippocampal-dependent tasks. A corresponding microarray analysis reveals that about 0.14% of hippocampal genes have an altered expression in the CPEB knockout mouse. These data suggest that CPEB-dependent local protein synthesis may be an important cellular mechanism underlying extinction of hippocampal-dependent memories.Keywords
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