A Method of Coating Non-Uniform Granular Particles

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Abstract
A method was developed for coating non-uniform granular particles In a uniform and controlled manner. Specific surface area was calculated based on the sieve-analysis data of uncoated theophylline granules which was used as the model compound. Theophylline granules were coated with different amounts of Eudraglt® L30D utilizing a Wurster coating apparatus. The in-vitro dissolution rate profiles of several batches were determined. Standard dissolution curves were established based on the amount of Eudraglt® L30D applied per unit area of theophylline granules. Using these curves as a standard, a prediction of dissolution rate could be made based on the knowledge of specific surface area of the theophylline granules and the amount of coating applied.

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