Studying “Secret Serums” — Toward Safe, Effective Ebola Treatments
- 18 September 2014
- journal article
- editorial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 371 (12) , 1086-1089
- https://doi.org/10.1056/nejmp1409817
Abstract
Ebola virus (EV), the cause of an ongoing deadly epidemic in West Africa, has been one of the world's most feared pathogens, causing catastrophic clinical disease and high mortality. Although the highest priority must be given to public health and infection-control measures that have contained past outbreaks, the current outbreak — the largest ever recorded — also highlights the need for effective treatment.Keywords
This publication has 6 references indexed in Scilit:
- High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola virusesAntiviral Research, 2014
- Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430Nature, 2014
- Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody CocktailScience Translational Medicine, 2013
- Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus InfectionsViruses, 2012
- Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaquesProceedings of the National Academy of Sciences, 2012
- Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept studyThe Lancet, 2010