Effects of Midazolam on Intracellular Calcium sup 2+ and Tension in Airway Smooth Muscles
Open Access
- 1 November 1995
- journal article
- laboratory investigation
- Published by Wolters Kluwer Health in Anesthesiology
- Vol. 83 (5) , 1009-1020
- https://doi.org/10.1097/00000542-199511000-00015
Abstract
Background: It has been demonstrated that a group of minor tranquilizers, benzodiazepines, are able to relax airway smooth muscles. To determine the underlying mechanisms of this phenomenon, the effects of midazolam on the intracellular Calcium2+ concentration ([Calcium2+]i) and tension in airway smooth muscles were investigated.Keywords
This publication has 29 references indexed in Scilit:
- Barbiturate-Benzodiazepine Interactions at the ??-Aminobutyric AcidA Receptor in Rat Cerebral Cortical SynaptoneurosomesAnesthesia & Analgesia, 1993
- Direct Inhibitory Mechanisms of Halothane on Canine Tracheal Smooth Muscle ContractionAnesthesiology, 1992
- Pharmacology of Dormicum (midazolam) and Anexate (flumazenil)Acta Anaesthesiologica Scandinavica, 1990
- Possible Mechanism of Benzodiazepine-Induced Relaxation of Vascular Smooth MuscleJournal of Cardiovascular Pharmacology, 1989
- Endothelin-induced CA-independent contraction of the porcine coronary arteryBiochemical and Biophysical Research Communications, 1989
- Cellular Mechanisms Regulating [Ca2+]i Smooth MuscleAnnual Review of Physiology, 1989
- Norepinephrine and GTP-γ-S increase myofilament Ca2+ sensitivity in α-toxin permeabilized arterial smooth muscleBiochemical and Biophysical Research Communications, 1988
- FlumazenilDrugs, 1988
- Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heartLife Sciences, 1985
- Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]R05-4864 and [3H]PK 11195, by thermodynamic studiesLife Sciences, 1983