ACUTE EFFECTS OF RAPAMYCIN ON GLOMERULAR DYNAMICS: A MICROPUNCTURE STUDY IN THE RAT
- 1 May 2000
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 69 (9) , 1946-1949
- https://doi.org/10.1097/00007890-200005150-00034
Abstract
The acute effects of cyclosporin (CsA, 20 mg/kg i.v.) and rapamycin (RAPA, 5 mg/kg i.v.) on glomerular dynamics were separately investigated by renal micropuncture in two groups of intact rats (group CsA and RAPA, respectively) and compared with vehicle-treated rats, used as controls (group CON). Left kidney glomerular filtration rate (GFR) was decreased by CSA (−35% vs. CON, P PKeywords
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