Changes in Number of α‐Adrenergic Receptor Subtypes in Hepatocytes from Rats Fed 3′‐Methyl‐4‐dimethylaminoazobenzene
- 1 June 1990
- journal article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 81 (6-7) , 557-559
- https://doi.org/10.1111/j.1349-7006.1990.tb02607.x
Abstract
Changes in numbers of α1‐ and α2‐adrenergic receptors in the plasma membranes of hepatocytes from female Donryu rats given feed containing 0.06% of the carcinogen 3′‐methyl‐4‐dimethylamino‐azobenzene (3′‐MeDAB), were examined. α1‐Adrenergic receptors, measured in terms of [3H]‐prazosin binding, decreased to half of the control 2 weeks after the start of this diet, then gradually decreased for the next 22 weeks. α2‐Adrenergic receptors, measured in terms of [3H]clonidine binding, transiently increased 3‐fold over the control at 2 weeks. These changes in the early period of the 3′‐MeDAB diet intake may be related to hepatocarcinogenesis.Keywords
This publication has 17 references indexed in Scilit:
- Characteristic β-adrenergic receptors in a rat ascites hepatoma cell line (AH130)Biochemical Pharmacology, 1989
- A comparison of adrenergic receptors of rat ascites hepatoma AH130 cells with those of normal rat hepatocytesCancer Letters, 1988
- Studies on Responsiveness of Hepatoma Cells to Catecholamines II. Comparison of β-Adrenergic Responsiveness of Rat Ascites Hepatoma Cells with Cultured Normal Rat Liver CellsThe Japanese Journal of Pharmacology, 1985
- Dose and sex dependent effects of 2-acetylamino-fluorene, 3′-methyl-4-dimethylaminoazobenzene and dl-ethionine in induction of γ-glutamyl transpeptidase-positive liver cell foci in ratsCancer Letters, 1983
- Alpha-adrenergic receptors in liver membranes: Delineation with subtype selective radioligandsLife Sciences, 1980
- Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholaminesLife Sciences, 1980
- Adrenergic receptor of the alpha1-subtype mediates the activation of the glycogen phosphorylase in normal rat liverBiochemical Pharmacology, 1980
- Effect of Treatment of Rats with Some Chemical Carcinogens on the Stimulatory Effect of Adrenaline on Cyclic AMP Accumulation in Liver SlicesActa Pharmacologica et Toxicologica, 1975
- Altered hormone control of cyclic AMP formation in isolated parenchymal liver cells from rats treated with 2-acetylaminofluoreneBiochimica et Biophysica Acta (BBA) - General Subjects, 1975
- Cyclic AMP metabolism in rat liver during 2-acetylaminofluorene carcinogenesisBiochimica et Biophysica Acta (BBA) - General Subjects, 1974