The Absorption and Metabolism of 3-Isopropylphenyl N-Methylcarbamate by Susceptible and Carbamate-Selected Strains of House Flies1

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Abstract
The absorption and metabolism of 3-isopropylphenyl N-methylcarbamate by a susceptible and a > 50-fold-resistant strain of house flies (Musca domestica L.) were investigated by the manometric cholinesterase inhibition method. Absorption, as determined by the rate of loss of external residue, was faster in resistant than in susceptible flies. However, four times as much toxicant accumulated internally in susceptible as in resistant flies within 2 hours after application. Of the absorbed material 85% was metabolized by the resistant flies and only 23% by the susceptible ones. Treatment of resistant flies with piperonyl butoxide blocked the detoxication mechanism and resulted in a pattern of absorption and internal accumulation of toxicant roughly similar to that observed in the susceptible flies.