THE ACCESSIBILITY OF THE GLOMERULAR VESSELS TO FLUID PERFUSED THROUGH THE RENAL PORTAL SYSTEM OF THE FROG'S KIDNEY

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Abstract
Since Nussbaum first utilized the double circulation of the frog''s kidney, it has been generally supposed that fluid entering the kidney through the renal-portal vein was confined in its circulation to the tubular capillaries and did not reach the glomeruli. In this understanding, perfusion experiments have been performed, some of which evidence secretion by the tubule cells; but the conclusions would be quite invalid had the venous perfusion fluid reached the glomeruli. In the present experiments, india ink and ferric ammonium citrate were added to the venous perfusion; and distribution of the fluid so perfused determined by subsequent identification of ink and prussian blue in frozen sections. Evidence was secured that the renal portal perfusion fluid reached a greater part of the glomeruli; this was true even when the venous perfusion was opposed by an arterial perfusion under a pressure 4 times that existent in the venous system. Some glomeruli contained fluid from both the arterial and venous per-fusions; others contained fluid from the latter alone. It is concluded that it is not justifiable to assume the renal portal perfusate to be wholly confined to tubular capillaries.

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