Interferon-γ Is Associated with the Surface of the Human Immunodeficiency Virus and Binds to thegagGene Product p17
- 1 December 1989
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 5 (6) , 605-612
- https://doi.org/10.1089/aid.1989.5.605
Abstract
Purified HIV-1 antigen preparations produced in cell culture were found to contain interferon-γ (IFN-γ). Electron microscopic examination of HIV-1 released by H9 cells, a cell line found to produce IFN-γ, showed the presence of this molecule on the surface of the virus particle. The HIV-1 protein pl7 was found to bind IFN-γ by a solid-phase radioimmunoassay. The specificity of the reaction was confirmed by Western blot analysis. This finding opens new questions about the biologic role of IFN-γ itself and of its interaction with HIV.This publication has 25 references indexed in Scilit:
- Neopterin as a marker for activated cell-mediated immunity: Application in HIV infectionImmunology Today, 1988
- Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptorCell, 1987
- Binding of HTLV-III/LAV to T4 + T Cells by a Complex of the 110K Viral Protein and the T4 MoleculeScience, 1986
- T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAVNature, 1984
- The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirusNature, 1984
- Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSScience, 1984
- Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDSScience, 1984
- Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)Science, 1983
- Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.Proceedings of the National Academy of Sciences, 1979
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970