Limited Genetic Diversity in Polynesians Reflected in the Highly Polymorphic 3’HVRα-Globin Gene Marker
- 1 January 1992
- journal article
- Published by S. Karger AG in Human Heredity
- Vol. 42 (3) , 157-161
- https://doi.org/10.1159/000154059
Abstract
Polynesians from five distinct island groups were studied with DNA probe alpha 3'HVR, a highly polymorphic VNTR (variable number of tandem repeats) minisatellite region associated with the alpha-globin gene cluster. Results showed a paucity of genetic heterozygosity together with clustering of alpha 3'HVR alleles with alpha-globin DNA haplotypes and alpha-globin gene rearrangements. This restricted diversity is consistent with population bottlenecks in the colonization of Polynesia.Keywords
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