THE MEASUREMENT OF PLASMA OESTRADIOL AND PROGESTERONE IN WOMEN WITH AMENORRHOEA TREATED WITH GONADOTROPHINS

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Abstract
Oestradiol and progesterone were measured in plasma of infertile women treated with human menopausal gonadotrophin (HMG) and human chorionic gonadotrophin (HCG). A total of 27 courses of treatment from 4 women were investigated. Plasma oestradiol was determined by a double competitive binding method and progesterone by competitive binding to corticosterone binding globulin. A relationship exists between the levels of plasma oestradiol in the follicular phase and the occurrence of ovulation as determined by plasma progesterone measurements in the luteal phase. Ovulation was not detected unless the oestradiol levels were in excess of 30 ng/100 ml plasma on the 7th day of treatment. The value of monitoring women undergoing gonadotrophin treatment by this procedure is discussed.