Experimental Infection of Dogs and Monkeys with Two Rabies Serogroup Viruses, Lagos Bat and Mokola (IbAn 27377). Gross Pathologic and Histopathologic Changes

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Abstract
Dogs and monkeys were inoculated intracerebrally or intramuscularly with Lagos bat virus or Mokola virus, two viruses serologically and morphologically related to rabies virus. All animals inoculated intracerebrally died, but some animals inoculated intramuscularly survived. One monkey inoculated intramuscularly with Lagos bat virus survived with a hemiparesis. In both dogs and monkeys that died there was a nonsuppurative meningoencephalomyelitis and ganglionitis. Lesions were more extensive than those reported after infection with street rabies virus. Intracytoplasmic inclusions, morphologically indistinguishable from Negri bodies, were seen in the central nervous system of monkeys, but not dogs, that died. With fluorescent-antibody microscopy, granular aggregations of viral antigen were observed in the cytoplasm of many neurons in the central nervous system. In some animals, the retina and ciliary body of the eye had focal inflammatory changes.

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