Serological α1‐Antichymotrypsin in Down's syndrome and Alzheimer's disease
- 1 August 1992
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 32 (2) , 193-197
- https://doi.org/10.1002/ana.410320211
Abstract
α1‐Antichymotrypsin (ACT) is a serine protease inhibitor that is markedly elevated in the serum and cerebrospinal fluid of patients with Alzheimer's disease (AD). Patients with Down's syndrome are known to develop neuropathological changes of AD by age 40 years and many become demented. Therefore, in the present study, we obtained serum ACT levels from patients with Down's syndrome and AD, diagnosed by autopsy or clinically, and healthy control subjects. Newman–Keuls' multiple range test revealed a significantly greater (p < 0.01) mean ACT level in the Autopsy AD (906.4 ± 94.64 mg/L) and Clinical AD (745.00 ± 59.95 mg/L) groups in contrast to the Old Control group (531.00 ± 23.05 mg/L). The mean ACT level of the Down's Syndrome group (513.33 ± 14.73 mg/L) was not significantly different from that of the Young Control subjects. Furthermore, we did not observe a positive correlation of ACT levels with age in the Down's Syndrome group, in spite of the age‐dependent premature increase in neuropathological changes of AD that are known to occur in patients with Down's syndrome. A positive correlation between serum ACT levels and the density of plaques or tangles, neuropathological hallmarks of AD, in brains of patients with AD also did not exist. Thus, our results suggest that ACT levels may not parallel the development of the classical neuropathological hallmarks of AD.Keywords
This publication has 11 references indexed in Scilit:
- The pathological association between down syndrome and Alzheimer diseasePublished by Elsevier ,2003
- Advances in Alzheimer's diseaseThe FASEB Journal, 1991
- α1‐Antichymotrypsin as a possible biochemical marker for Alzheimer‐type dementiaAnnals of Neurology, 1990
- The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's diseaseActa Neuropathologica, 1990
- α1-Antichymotrypsin is associated solely with amyloid deposits containing the β-protein. Amyloid and cell localization of α1-antichymotrypsinNeurobiology of Aging, 1990
- Distribution of the Protease Inhibitor α1-Antichymotrypsin in Cerebral and Systemic AmyloidJournal of Neuropathology and Experimental Neurology, 1990
- Cerebral amyloidosis, ageing and Alzheimer's disease; A contribution from studies on Down's syndromeNeurobiology of Aging, 1989
- Comparison of rate of annual change of mental status score in four independent studies of patients with Alzheimer's diseaseAnnals of Neurology, 1988
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- HUMAN PLASMA PROTEINASE INHIBITORSAnnual Review of Biochemistry, 1983