The Specificity Of Rabbit Antisera To Herpesvirus Hominis And Its Dependence On The Dose Of Virus Inoculated

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Abstract
Summary Typing of strains of Herpesvirus hominis according to the method of Pauls and Dowdle can be performed in BHK cells instead of in primary rabbit kidney cells. The modified method has the advantage of a reduction in incubation time and the convenience of working with a semi-continuous cell line. The concentration of virus antigen inoculated into rabbits to produce typing antisera has an effect on the cross-reactivity of the sera obtained. Higher immunising doses of virus produce antisera with higher degrees of cross-reactivity than is found in antisera produced in response to low immunising doses of virus.