Influence of Esculetin on Incidence, Proliferation, and Cell Kinetics of Mammary Carcinomas Induced by 7,12‐Dimethylbenz[α]anthracene in Rats on High‐ and Low‐fat Diets

Open Access
Publisher Website
Google Scholar
Abstract
The effects of a high‐fat diet and esculetin were investigated on 7,12‐dimethylbenz[α]anthracene (DMBA)‐induced mammary carcinogenesis in female Sprague‐Dawley rats. Rats were given a 5‐mg dose of DMBA. Seven days later, they were fed either a high‐fat (20% soybean oil) or low‐fat (0.5% soybean oil) diet. A half of the rats received diets containing 0.03% esculetin. Esculetin significantly inhibited tumor incidence, growth and cell kinetics of the tumor in the rats fed the high‐fat and the low‐fat diets. Our findings indicate that DMBA‐induced mammary tumorigenesis is affected by lipoxygenase products.