STUDIES OF THE EFFECT OF IRRADIATION OF CELLULAR PARTICULATES. VI. COMPARISON OF UNCOUPLING AT THE THREE PHOSPHORYLATING SITES

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Abstract
White male rats of Sprague-Dawley strain were exposed to 1000 r total-body γ-irradiation. Measurements of the uncoupling at each of the three phosphorylating sites in mitochondria isolated from liver and spleen were made. The results indicate that the terminal step (oxidation of reduced cytochrome-c) is the most sensitive of the three and that the great majority, if not all, of the observed uncoupling may result from damage to this step.