HEREDITARY C5 DEFICIENCY IN MAN .3. STUDIES OF HEMOSTASIS AND PLATELET RESPONSES TO ZYMOSAN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 118  (1) , 12-16
Abstract
Platelet-rich-plasma from 2 hemostatically normal individuals, genetically lacking the 5th component of complement (C5D), failed to exhibit normal platelet aggregation, or serotonin release, in the presence of zymosan. This abnormality resided in the C5D plasma rather than in the platelets, as demonstrated by the inability of the deficient plasma to activate zymosan for the aggregation of washed normal platelets. The defect could be corrected by the addition of normal plasma, normal serum or highly purified human C5. A plasma abnormality similar to that found in the C5D individuals was noted in the plasmas deficient in C3, C6 and C7; C8 plasma D behaved normally. This platelet reaction apparently requires late acting C components, perhaps as the .**GRAPHIC**. complex [activated C5, C6, C7 complex] bound to the zymosan particles.

This publication has 1 reference indexed in Scilit: