Elucidation of the receptor‐bound conformation of the enkephalins
- 1 January 1978
- journal article
- research article
- Published by Wiley in Journal of Supramolecular Structure
- Vol. 9 (1) , 27-39
- https://doi.org/10.1002/jss.400090104
Abstract
The biologically relevant conformers of enkephalin predicted by solid state, solution state, and theoretical energy studies have been compared with the published structure-activity data on these compounds. No conformational technique proposes a model consistent with all the pharmacological data; the shortcomings of each approach are evaluated. An alternative approach, which correlates the structure-activity data of opiate compounds with that of the enkephalins, is described and shown to produce a model consistent with the available structure-activity data.Keywords
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