Impact of age and gender on in-hospital and late mortality after acute myocardial infarction: increased early risk in younger women

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Abstract
Aims To determine whether sex differences of in-hospital and after-discharge mortality differ according to the age. Methods and results Data of 4347 consecutive patients hospitalized within 48 h of the onset of acute myocardial infarction (AMI) were analysed. Patients were classified according to median age (68 years): Group 1 (G1) (308 women, 30–67 years), G2 (1878 men, 30–67 years), G3 (860 women, 68–89 years), and G4 (1301 men, 68–89 years). In both age groups, women were older, had more frequent co-morbidities, lower rate of reperfusion therapy, and received less anti-platelet agents, β-blockers, and statins than men. The overall 1-year mortality was higher in women (25% vs. 16% in men, PConclusion The higher 1-year mortality following AMI in women is explained by the higher risk of death in young women during the first days of hospitalization. Further investigations are crucial to determine the cause in order to improve the chance of survival in younger women.