Trisomy 13 in bone marrow cells in acute myelocytic leukemia and myelofibrosis

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Abstract
Trisomy 13 was identified in 2 additional patients with hematologic malignancies involving the hematopoietic stem cell: a 75 yr old female with acute myelocytic leukemia and a 64 yr old female with agnogenic myelofibrosis and myeloid metaplasia. Chromosome analysis of the direct bone-marrow preparation showed 100% of cells with trisomy 13 in the 1st and 10% of cells in the 2nd. A previous patient with pH1 negative chronic myelogenous leukemia in whom 100% of the marrow cells showed an identical trisomy had been reported. The probability of finding 3 such patients was calculated to be 0.05-0.08, implying that trisomy 13 may be another nonrandom chromosomal aberration associated with malignancies of hematopoietic pluripotent stem cell.