Determination of the minimal inhibitory concentration of Amphotericin B and Miconazole for 21 strains of Aspergillus

Publisher Website
Google Scholar
Abstract
The susceptibility of 21 strains ofAspergillus (11 ofA. fumigatus, 8 ofA. niger, and 2 ofA. flavus) isolated from human pathologic specimens to Amphotericin B and Miconazole has been comparatively studied. Determination of the minimal inhibitory concentration of both drugs in a liquid medium showed a noticeably variability for the different strains. The values obtained for Amphotericin B varied between 0.25μg/ml (2 strains) and 1.25μg/ml (5 strains) after 48 hours, and between 1.25μg/ml (1 strain) and 50μg/ml (1 strain) after 10 days. For Miconazole the results varied between 0.1μg/ml (1 strain) and 25μg/ml (1 strain) after 48 hours of incubation, and between 0.5μg/ml (5 strains) and > 100μg/ml after 10 days. The variability of these results indicates the usefulness of carrying ourin vitro sensitivity studies whenever it is possible.