A HORMONE MECHANISM FOR GALL-BLADDER CONTRACTION AND EVACUATION

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Abstract
A non-toxic, vaso-dilatin free extract of the upper intestinal mucosa has been prepared which causes contraction and evacuation of the gall-bladder on intravenous injection. The term "cholecystokinin" is proposed as a name for the hormone. The pressure produced by gall-bladder contraction after one injection of "cholecystokinin" is a maximum of 11.5 cm. of bile and a minimum of 1.0 cm.; after a series of injections the pressure averaged 10.0 cm. in anesthetized dogs and 20.0 cm. in unanesthetized dogs. The average du-raton of contract;on after a single dose is 15 min.; following a series of doses the gall-bladder relaxes in 30 to 60 min.

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