Studies on the Immunizing Substances in Pneumococci

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Abstract
Summary: Pneumococci, both type I and type II, dried by application of acetone followed by vacuum desiccation, retain their antigenicity. The cell may be divided into acid soluble and acid insoluble constituents. The acid soluble fraction possesses most of the immunizing activity of the cell; the immunity obtained by injecting this fraction into white mice is largely specific. The acid insoluble fraction, perhaps containing some intact cells, also possesses a small amount of the immunizing substance and produces in white mice a heterologous immunity. With the method used in this study, at least 90 per cent of the immunizing substance in the acid soluble fraction may be precippitated by ethyl alcohol or by acetone. The work here reported is limited to tests on white mice, and to antigenicity as produced by a single injection of the immunizing substance.

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