Direct Observation of Native DNA Structures with the Scanning Tunneling Microscope
- 20 January 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 243 (4889) , 370-372
- https://doi.org/10.1126/science.2911747
Abstract
Uncoated double-stranded DNA dissolved in a salt solution was deposited on graphite and imaged in air with the scanning tunneling microscope (STM). The resolution was such that the major and minor grooves could be distinguished. The pitch of the helix varied between 27 and 63 angstroms in the images obtained. Thus the STM can be useful for structural studies of a variety of uncoated and isolated biomolecules.Keywords
This publication has 12 references indexed in Scilit:
- Scanning Tunneling Microscopy Observations of Benzene Molecules on the Rh(111)-(3 × 3) (+ 2CO) SurfacePhysical Review Letters, 1988
- Imaging of liquid crystals using a tunnelling microscopeNature, 1988
- Scanning Tunneling Microscopy of recA-DNA Complexes Coated with a Conducting FilmScience, 1988
- Observation of individual organic molecules at a crystal surface with use of a scanning tunneling microscopePhysical Review Letters, 1988
- Scanning tunneling microscopy of Langmuir–Blodgett films on graphiteJournal of Vacuum Science & Technology A, 1988
- Summary Abstract: Dipalmitoylphosphatidylcholine–Langmuir–Blodgett films on various substrates [Si(111), Au, Sn] studied by scanning tunneling microscopyJournal of Vacuum Science & Technology A, 1988
- Structure and thermal stability of the Au(334) surface and Au(111) thin films in air: A scanning tunneling microscopy studyApplied Surface Science, 1987
- Scanning tunneling microscopy of individual molecules of copper phthalocyanine adsorbed on polycrystalline silver surfacesSurface Science, 1987
- Scanning tunneling microscopyJournal of Applied Physics, 1987
- Determination of surface topography of biological specimens at high resolution by scanning tunnelling microscopyNature, 1985