Does the synthesis of ribosomal RNA take place-within nucleolar fibrillar centers or dense fibrillar components?
- 1 January 1989
- journal article
- research article
- Published by Wiley in Biology of the Cell
- Vol. 65 (1) , 79-82
- https://doi.org/10.1016/0248-4900(89)90013-0
Abstract
By means of immunocytochemistry performed on cryosections of cultured cells, RNA polymerase I was localized mainly to nucleolae fibrillar centers. The labelling of nucleolar dense fibrillar components was low and depended on the cell type. In contrast, DNA topoisomerase I and RNP complexes containing U3 snRNA were enriched in dense fibrillar components, their occurrence in fibrillar centers being usually much less.Keywords
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