The steady progress of physics requires for its theoretical formulation a mathematics that gets continually more advanced. This is only natural and to be expected. What, however, was not expected by the scientific workers of the last century was the particular form that the line of advancement of the mathematics would take, namely, it was expected that the mathematics would get more and more complicated, but would rest on a permanent basis of axioms and definitions, while actually the modern physical developments have required a mathematics that continually shifts its foundations and gets more Non-euclidean geometry and non-commutative algebra, which were at one time considered to be purely fictions of the mind and pastimes for logical thinkers, have now been found to be very necessary for the description of general facts of the physical world. It seems likely that this process of increasing abstraction will continue in the future and that advance in physics is to be associated with a continual modification and generalisation of the axioms at the base of the mathematics rather than with a logical development of any one mathematical scheme on a fixed foundation. There are at present fundamental problems in theoretical physics awaiting solution, e.g. , the relativistic formulation of quantum mechanics and the nature of atomic nuclei (to be followed by more difficult ones such as the problem of life), the solution of which problems will presumably require a more drastic revision of our fundamental concepts than any that have gone before. Quite likely these changes will be so great that it will be beyond the power of human intelligence to get the necessary new ideas by direct attempts to formulate the experimental data in mathematical terms. The theoretical worker in the future will therefore have to proceed in a more indirect way. The most powerful method of advance that can be suggested at present is to employ all the resources of pure mathematics in attempts to perfect and generalise the mathematical formalism that forms the existing basis of theoretical physics, and after each success in this direction, to try to interpret the new mathematical features in terms of physical entities (by a process like Eddington’s Principle of Identification).