Purified Duck Embryo Rabies Vaccine
- 18 July 1977
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 238 (3) , 218-220
- https://doi.org/10.1001/jama.1977.03280030026014
Abstract
Seroconversion and adverse reaction rates were studied in 92 persons given four or five doses in a two-week period of duck embryo rabies vaccine (DEV) or duck embryo rabies vaccine purified by ultracentrifugation (P-DEV). Mouse-neutralizing antibodies developed in 78 of 92 (84.8%) persons in these accelerated schedules. There were no significant differences in the frequency of antibody conversion or in geometric mean titers of antibody between persons given either vaccine. However, local and systemic adverse reactions were substantially less common with P-DEV. These data suggest that four or five doses of DEV or P-DEV given in a two-week course can be used for preexposure prophylaxis in situations where the more drawn-out regimens would result in continuation of a high-risk of rabies exposure. The antibody response of persons given this more accelerated regimen must be determined. (JAMA238:218-220, 1977)Keywords
This publication has 3 references indexed in Scilit:
- Human cell culture rabies vaccine. Antibody response in manPublished by American Medical Association (AMA) ,1973
- EFFICACY OF RABIES VACCINE PREPARED FROM VIRUS GROWN IN DUCK EMBRYOThe Lancet, 1970
- Indirect Fluorescent Antibody and Serum Neutralization Response in Pre-exposure Prophylaxis Against RabiesAnnals of Internal Medicine, 1965