Characterization of SV40-Transformed Human Liver Cells Before and After Passage Through Crisis
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 17 (4) , 222-227
- https://doi.org/10.1159/000149292
Abstract
SV40-transformed human liver cells could be passed through crisis after transfection with various DNAs (SV40, BKV, or salmon sperm). The pre- and post-crisis cells were compared with respect to growth behavior and the state of the viral genome. Comparison of the viral inserts in the pre- and post-crisis cells showed minor changes in the integration pattern of the SV40 DNA after recovery from crisis.Keywords
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