A COMPARISON OF THE EFFECTS OF A.T. 10 (DIHYDROTACHYSTEROL) AND VITAMIN D ON CALCIUM AND PHOSPHORUS METABOLISM IN HYPOPARATHYROIDISM

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Abstract
1. The actions of A.T. 10 and of vit. D on the Ca and P metabolism of 3 patients with hypoparathyroidism were studied; in one of the three patients the effect of the parathyroid hormone was likewise detd. 2. Both vit. D and A.T. 10 had the same fundamental actions-to increase Ca absorption from the gut and to increase P excretion in the urine; the ratio of the latter action to the former, however, was apparently greater with A.T. 10, which may explain why A.T. 10 is not antirachitic. 3. The action of vit. D was slower in coming on and lasted longer than that of A.T. 10. 4. The parathyroid hormone resembled A.T. 10 as regards its property of causing a markedly in-increased urinary P excretion but differed in that it probably had no primary action on Ca absorption from the gut. 5. Because of the similarity between the actions of the parathyroid hormone and of A.T. 10, the latter drug is a most efficacious therapeutic agent in the treatment of hypoparathyroidism.

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