Daughterless X Sxr/Y Sxr mice

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Abstract
McLaren and Monk and Cattanach et al. reported that T(X; 16)16H/X Sxr mice, in which the X chromosome bearing Sxr is the inactivated X chromosome, can develop as fertile females. By mating such females to X/Y Sxr males, it was possible to produce mice homozygous for Sxr. Two X Sxr/Y Sxr males were identified which together fathered 141 sons and 1 daughter. The single daughter proved to be XO, indicating a non-disjuctional event with neither paternal sex chromosome being transmitted. X Sxr/Y Sxr mice are viable and fertile, and that all their progeny, provided they receive a paternal sex chromosome, develop as males.