Current Concepts of Jaundice, with Particular Reference to Hepatitis

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Abstract
JAUNDICE — or yellow staining of the skin, mucous membranes and scleras due to the presence of excessive amounts of bilirubin in the blood — can probably be produced by as great a variety of pathologic processes as any physical finding encountered in the practice of medicine.1 2 3 4 Since bilirubin is derived from hemoglobin, an understanding of the numerous mechanisms by which jaundice may develop is best approached by a review of certain aspects of the normal metabolism of hemoglobin.Normal Bile-Pigment MetabolismAs shown in Figure 1, the porphyrin rings of the hemoglobin molecule are made up of four pyrrol nuclei . . .
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