HIV-specific CD8+ T-cell immune responses and viral replication
- 1 November 1993
- journal article
- review article
- Published by Wolters Kluwer Health in AIDS
- Vol. 7, S81-86
- https://doi.org/10.1097/00002030-199311002-00016
Abstract
To review current knowledge of CD8+ T cells in relation to their effect on the replication of HIV and on disease progression. Both CD8+ cytotoxic T lymphocytes capable of killing cells expressing HIV antigens and CD8+ lymphocytes that suppress HIV replication in vitro are detectable in response to HIV infection. These CD8+ T cells may help to maintain a low viral load in vivo, thus allowing a long asymptomatic period of infection.Keywords
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