Physical factors and cardiac adaptation

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Abstract
Studies were made in the canine heart to determine the extent to which changes in the sequence of ventricular contraction or in ventricular compliance contribute to the adaptation of the heart during aortic pressure elevation. The results of the experiments show that homeometric autoregulation cannot be explained on the basis of a two-step Frank-Starling effect as a result of isovolumic circumferential changes and that, although a relative change in ventricular compliance is observed when aortic pressure is increased, the change in compliance cannot account for the phenomenon of homeometric autoregulation.

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