Relationship Between Amount and Type of Dietary Fat in Promotion of Mammary Carcinogenesis Induced by 7,12-Dimethylbenz[a]anthracene2

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Abstract
Female Sprague-Dawley rats were fed semipurified diets containing various fats, either alone or in combination, to provide different amounts of dietary fat and linoleic acid. One week before commencing the diets, each rat received an intragastric doae of the carcinogen 7,12-dimethylbenz[a]anthracene. Rats fed diets containing mixtures of 3% sunflower seed oil and 17% of either tallow or coconut oil developed twice as many tumors as those led 3% sunflower seed oil or 20% of either saturated fat alone. Tumor yields in the rats led these mixed-fat diets were comparable to those in rats fed a 20% lard diet, which provided about the same amount of linoleic acid. No lurther increase in tumor yield was observed in rats fed a 20% sunflower seed oil diet that contained more than five time as much linoleic acid. These results ahow that a certain amount of polyunsaturated fat, as well as a high level of dietary fat, is required to promote mammary carcinogenesis.