An improved method for detecting and delineating genomic regions with altered gene expression in cancer
Open Access
- 21 January 2008
- journal article
- method
- Published by Springer Nature in Genome Biology
- Vol. 9 (1) , 1-15
- https://doi.org/10.1186/gb-2008-9-1-r13
Abstract
Genomic regions with altered gene expression are a characteristic feature of cancer cells. We present a novel method for identifying such regions in gene expression maps. This method is based on total variation minimization, a classical signal restoration technique. In systematic evaluations, we show that our method combines top-notch detection performance with an ability to delineate relevant regions without excessive over-segmentation, making it a significant advance over existing methods. Software (Rendersome) is provided.Keywords
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