Effect of Adrenocorticotropic Hormone (ACTH) and Cortisone on Serum Proteins in Various Diseases

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Abstract
In 15 patients treated with ACTH and cortisone the serum proteins were examined before and after treatment by means of a method of fractionated salting-out with ammonium sulfate and detn. of the protein content in the different fractions by means of u.-v. spectrophotometry. As a rule, a fall of the protein values was seen in the course of treatment in certain salting-out-intervals of the globulins, and this fall occurred more frequently when the treatment produced a good clinical effect than when this was not the case. In this small and heterogeneous series of cases there seems to be a connection between the protein values in certain salting-out-intervals before the treatment and the clinical effect of the latter.