Fate of hydralazine in man. II. Formation of tetrazolo(5,1-a)phthalazine in vivo and inhibition of monoamine oxidase by this metabolite.
- 1 January 1981
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 29 (9) , 2683-2685
- https://doi.org/10.1248/cpb.29.2683
Abstract
Tetrazolo[5,1-.alpha.]phthalazine (tetra-P) was detected in the urine of a patient on hydralazine [an automonic antihypertenive which increases renal blood flow] treatment. Tetra-P is a new type of monoamine oxidase (MAO) inhibitor.This publication has 2 references indexed in Scilit:
- Fate of hydralazine in man. I. Reactions under gastric conditions.CHEMICAL & PHARMACEUTICAL BULLETIN, 1979
- A sensitive fluorometric assay of human platelet monoamine oxidase and its application to assessment of monoamine oxidase inhibitor.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978