Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults

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Abstract
STUDY OBJECTIVE To determine whether long term weight gain and weight loss are associated with subsequent risk of type 2 diabetes in overweight, non-diabetic adults. DESIGN Prospective cohort. Baseline overweight was defined as BMI⩾27.3 for women and BMI⩾27.8 for men. Annual weight change (kg/year) over 10 years was calculated using measured weight at subjects' baseline and first follow up examinations. In the 10 years after measurement of weight change, incident cases of diabetes were ascertained by self report, hospital discharge records, and death certificates. SETTING Community. PARTICIPANTS 1929 overweight, non-diabetic adults. MAIN RESULTS Incident diabetes was ascertained in 251 subjects. Age adjusted cumulative incidence increased from 9.6% for BMICONCLUSIONS Weight gain was associated with substantially increased risk of diabetes among overweight adults, and even modest weight loss was associated with significantly reduced diabetes risk. Minor weight reductions may have major beneficial effects on subsequent diabetes risk in overweight adults at high risk of developing diabetes.