Single-Dose Kinetics of Nifedipine in Rat Plasma and Brain
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 36 (3) , 183-187
- https://doi.org/10.1159/000138382
Abstract
Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 mg/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethane-pentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase Cig column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 μg/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.Keywords
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