Genetic Expression of Wilson's Disease in Cell Culture: A Diagnostic Marker
- 18 April 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 208 (4441) , 299-300
- https://doi.org/10.1126/science.7367859
Abstract
Wilson's disease fibroblasts have an elevated intracellular copper concentration as compared to cultured control cells. A decreased ratio of copper to protein was observed in cytoplasmic protein (or proteins) having a molecular weight ≥ 30,000 in Wilson's disease cells. The results of this culture study indicate its potential importance in the early unequivocal diagnosis of this disorder.Keywords
This publication has 10 references indexed in Scilit:
- Metal-binding studies of metallothioneins in Menkes kinky hair diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1978
- Cell culture studies of menkes kinky hair diseaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1978
- Diagnostic Dilemmas of Wilson's Disease: Diagnosis and TreatmentPediatrics, 1978
- Diagnosis of Treatable Wilson's DiseaseNew England Journal of Medicine, 1978
- 64Cu Metabolism in Menkes and Normal Cultured Skin FibroblastsPediatric Research, 1978
- Wilson's Disease: Identification of an Abnormal Copper-Binding ProteinScience, 1973
- Biological Applications of the Carbon Rod Atomizer in Atomic Absorption Spectroscopy. 2. Determination of Copper in Small Samples of TissueClinical Chemistry, 1972
- Determination of Copper in Fingernails by Atomic Absorption with the Graphite FurnaceClinical Chemistry, 1972
- THE MECHANISM OF COPPER DEPOSITION IN THE LIVER IN HEPATOLENTICULAR DEGENERATION (WILSONʼS DISEASE)The Lancet Healthy Longevity, 1956
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951